Rodent Glucose Clamp

For Rats

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Maximize the accuracy and efficiency of your rat insulin and glucose studies with high-quality supplies from SAI.

Conducting insulin sensitivity studies can quickly become complex, but we’re here to simplify the process and support your research goals. Whether your study involves Glucose Tolerance Tests (GTT), Hyperglycemic Clamp techniques, or Hyperinsulinemic-Euglycemic Clamp protocols, we provide expert guidance and carefully selected recommendations to ensure accurate and reproducible results. Explore our resources and product suggestions below to streamline your workflow and achieve reliable outcomes in your insulin sensitivity research.

Supplies for ITT and GTT Studies

In this study design, a loading dose of glucose (gtt) or insulin (itt) is followed by intermittent blood sampling. The dose is typically administered orally, and since multiple blood samples are needed, an access port is the best tool to make catheter access quick and easy.

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    Rodent jugular vein catheters

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  • Rodent Disposable Feeding Needles

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  • CannuLock™ Catheter Access Ports, Sterile

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Supplies for Hyperglycemic Clamp Studies

In this study design, IV glucose is infused and adjusted to reach a steady state, followed by intermittent blood sampling to establish glucose levels. Since the rat must be tethered, and low-stress, the CannuLock™ Catheter Access Button™ is an ideal tool.

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    Rodent jugular vein catheters

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  • Rat Femoral Polyurethane Artery Catheter

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  • Bile collection 25G swivel to tube extension lines 3/pk

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  • CannuLock™ Catheter Access Ports, Sterile

    Select options This product has multiple variants. The options may be chosen on the product page

  • Cannulock™ Catheter Access Button Standard and Shunting Caps

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  • CannuLock™ Catheter Access Buttons, 22G

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  • Quick Connect Tethers, Cannulock™ Catheter Access Button

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  • Rodent Swivel-Tether Connectors

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Supplies for Hyperinsulinemic-Euglycemic Clamp Studies

This protocol uses an IV infusion of insulin to set a baseline, as well as variable rate infusion of glucose (into the same IV line). It’s also common to incorporate an additional channel for IV dosing of an experimental compound. Intermittent blood sampling determines the impact of the drug administration on the rat.